Sickle cell trait is written AS. People with AS are generally well and fertile. If both partners are carriers of a sickle or C variant, there is a one-in-four chance in each pregnancy of a child with sickle-cell disease. Counselling explains the options, which may include prenatal diagnosis or PGT-M.
Fertility Glossary
Sickle-cell trait
Carrying one sickle gene (AS); usually healthy.