The agonist protocol is an IVF stimulation approach in which a GnRH agonist medicine is used to suppress the pituitary gland's own hormone signals, either starting in the cycle before stimulation (long protocol) or at the start of the treatment cycle (short or flare protocol), before ovarian-stimulating medicines begin. This suppression is intended to prevent a premature LH surge that could otherwise cause early ovulation before egg retrieval. Agonist-based protocols have been used in IVF for many years and remain an option for certain individuals, chosen by the treating fertility specialist based on ovarian reserve, prior cycle response and overall health. This entry does not describe medicine names or doses.
Also known as: GnRH agonist protocol, long agonist protocol
Related India guides
Sources
- ICMR Standard Treatment Workflows (icmr.gov.in/standard-treatment-workflows-stws)
Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.