Assisted hatching and embryo glue

Assisted hatching is a laboratory technique in which the embryologist creates a small opening in an embryo's outer shell, the zona pellucida, before transfer, intended to make it easier for the embryo to hatch out and potentially implant. Embryo glue, also called hyaluronan transfer medium, is a fluid containing hyaluronan, used to carry the embryo into the uterus during transfer, on the idea that it may support attachment. Both are offered by some clinics as additional-cost add-ons. Evidence for a meaningful improvement in live birth rates from either technique, across the general IVF population, is limited and inconsistent, though they may be considered in specific circumstances, such as a thickened zona pellucida for assisted hatching. Ask your clinic to explain the evidence and cost clearly before agreeing to either.

Also known as: assisted hatching, embryo glue, hyaluronan transfer medium

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.