Hypogonadotropic hypogonadism

Hypogonadotropic hypogonadism is a condition where the pituitary gland does not produce enough of the hormones (LH and FSH) that normally signal the testes to make testosterone and sperm. It can be present from birth, sometimes linked to a genetic cause and reduced or absent sense of smell (Kallmann syndrome), or can be acquired later from a pituitary tumour, high prolactin levels, certain medicines including anabolic steroids, significant weight change, or other pituitary or hypothalamic disorders. Because the testes themselves are usually capable of function if properly stimulated, hormone treatment can often restore testosterone production and, over a period of months, sperm production as well, in contrast to conditions where the testis itself cannot respond to hormonal signals. Diagnosis involves blood tests for LH, FSH, testosterone and sometimes prolactin, with treatment planned and monitored by a specialist.

Also known as: hypogonadotropic hypogonadism in men, pituitary cause of infertility

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.