Advanced sperm selection add-ons (PICSI, IMSI, MACS, microfluidic selection)

Several additional techniques exist for selecting sperm before ICSI beyond standard preparation. PICSI selects sperm based on binding to hyaluronan, a substance found around the egg. IMSI uses very high magnification imaging to examine sperm shape in more detail before selection. MACS (magnetic-activated cell sorting) and microfluidic sperm selection are methods that aim to separate healthier-looking or more motile sperm using magnetic or fluid-flow-based sorting, as alternatives or additions to conventional sperm preparation. These techniques are offered by some clinics, usually for an additional fee, on the basis that they may improve sperm selection. Current evidence has not consistently shown that any of them reliably improve fertilisation, embryo quality or live birth rates for the general IVF population, although research continues and some may have a role in specific situations, such as high sperm DNA fragmentation. Clinics offering these add-ons should explain the evidence honestly so you can make an informed decision about the added cost.

Also known as: PICSI, IMSI, MACS, microfluidic sperm selection, sperm selection add-ons

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.