PGT-M (preimplantation genetic testing for monogenic disorders)

PGT-M (preimplantation genetic testing for monogenic disorders) is used when one or both partners are known carriers of, or affected by, a specific single-gene (monogenic) condition — for example beta-thalassaemia, sickle-cell disease or spinal muscular atrophy — and wish to reduce the chance of having a child affected by that particular condition. It requires prior genetic testing of the couple (and sometimes other family members) to identify the exact variant, followed by development of a customised test for their embryos. PGT-M only tests for the specific condition it is designed for; it does not screen for unrelated genetic conditions or guarantee an otherwise healthy pregnancy. It is carried out alongside IVF, with embryo biopsy and specialist laboratory analysis, and needs genetic counselling before and after testing. Because it involves selecting embryos, PGT-M in India must never be used, directly or indirectly, to determine or select the sex of an embryo, which is prohibited under the PCPNDT Act.

Also known as: PGT-M, preimplantation genetic testing for monogenic disorders, single gene testing of embryos

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.