Recurrent implantation failure (RIF)

Recurrent implantation failure (RIF) is a term used when good-quality embryos fail to implant after being transferred over more than one IVF cycle. There is no single, universally agreed definition of RIF in terms of the exact number of failed transfers or embryos required to use the term, and different clinics and professional bodies use somewhat different criteria, which is worth understanding when the term is discussed. Possible contributing factors that may be considered include uterine or endometrial issues, embryo factors (including chromosomal status), and, in some cases, immunological or other causes that remain areas of ongoing research. It is important to know that the evidence supporting many additional tests and treatments proposed for RIF is limited or still developing, and not all such tests have been shown to improve outcomes; this should be discussed openly with the treating clinic before pursuing further testing. Management is individualised, and may include a review of the uterine cavity, embryo assessment, and consideration of PGT-A testing in future cycles where appropriate, based on a discussion between the patient and their fertility specialist.

Also known as: RIF, repeated implantation failure, embryo not implanting

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.