Thrombophilia

Thrombophilia describes an increased tendency for the blood to clot abnormally, which can be inherited, such as Factor V Leiden, the prothrombin gene mutation, and protein C, protein S or antithrombin deficiency, or acquired, as in antiphospholipid syndrome. Some inherited thrombophilias have been studied in relation to recurrent pregnancy loss and certain pregnancy complications, though the evidence linking specific inherited thrombophilias to pregnancy loss is more limited than for antiphospholipid syndrome. Routine thrombophilia testing is not appropriate or recommended for everyone trying to conceive or having fertility treatment; it is generally considered selectively, for example where there is a personal or strong family history of blood clots or recurrent pregnancy loss, and decisions about testing and any treatment should be made individually with a specialist rather than requested as a general precaution.

Also known as: Factor V Leiden, prothrombin gene mutation, protein C deficiency, protein S deficiency, antithrombin deficiency, clotting disorder and pregnancy

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.