Antiphospholipid syndrome (APS)

Antiphospholipid syndrome is an autoimmune condition in which the body produces antibodies, including lupus anticoagulant, anticardiolipin antibody and beta-2 glycoprotein I antibody, that increase the risk of blood clots and are associated with certain patterns of pregnancy loss, including recurrent early miscarriage and some later pregnancy complications. It is one of the treatable causes identified during evaluation for recurrent pregnancy loss. Diagnosis requires positive antibody blood tests on two occasions at least twelve weeks apart, together with a defined clinical history of pregnancy loss or clotting; a single positive test is not enough to confirm the diagnosis. Antiphospholipid syndrome testing is not something every person trying to conceive needs, and testing is usually reserved for those with a relevant history of recurrent loss or clotting, as recommended by a specialist. If diagnosed, treatment in a future pregnancy is managed jointly between a gynaecologist and physician, since it may involve medication that needs specialist monitoring.

Also known as: APS, lupus anticoagulant, anticardiolipin antibody, beta-2 glycoprotein I antibody

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.