Fertilisation failure

Fertilisation failure means none, or very few, of the mature eggs fertilised. Causes include sperm factors, egg factors such as a failure to activate, or immature eggs. It is distressing and often unexpected. Clinics review the cycle afterwards and may change the approach — for example using ICSI in a subsequent cycle where conventional IVF was used.

Also known as: failed fertilisation, no fertilisation

Last reviewed: 8 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.