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A–Z Fertility Glossary

299 fertility terms explained in plain language.

299 terms

2

A

Above-threshold benefit
South African healthcare & funding

Scheme cover that resumes once annual day-to-day spending passes a set amount.

Academic hospital

A university-affiliated public hospital, where public-sector fertility care is concentrated.

Adenomyosis
Female fertility

Endometrial-type tissue growing within the muscular wall of the womb.

Adverse drug reaction reporting
South African healthcare & funding

Telling SAHPRA about a suspected side effect or product problem.

Agonist trigger
Medicines & protocols

Using a GnRH agonist instead of hCG for final egg maturation.

Amenorrhoea
Female fertility

The absence of periods.

AMH (anti-Müllerian hormone)

A blood test indicating how many eggs remain, not their quality.

AMH testing
Tests & investigations

The blood test used to estimate ovarian reserve; can be taken any cycle day.

Anaemia

A low haemoglobin level, most often from iron deficiency.

Androgens
Hormones

A group of hormones including testosterone, raised in some women with PCOS.

Andrology laboratory
Clinics, laboratory & costs

The laboratory area dealing with sperm testing and preparation.

Aneuploidy
Genetics

Having too many or too few chromosomes.

Anonymous donor
Donor treatment & family building

A donor whose identity is not disclosed to the recipients.

Anovulation
Female fertility

Cycles in which no egg is released.

Antagonist protocol
Medicines & protocols

An IVF plan where the LH-blocking medicine starts partway through stimulation.

Antiphospholipid syndrome (APS)
Tests & investigations

An immune condition linked with clotting and recurrent pregnancy loss.

Antisperm antibodies
Male fertility

Immune proteins that attach to sperm and hamper their movement.

Antral follicle count (AFC)
Tests & investigations

The number of small resting follicles counted on an ultrasound scan.

Arrested embryo
Eggs, sperm & embryos

An embryo that stops developing in the laboratory.

Asherman syndrome
Female fertility

Extensive scarring inside the womb causing very light or absent periods.

Assisted hatching
IVF & IUI

Thinning or opening the embryo's outer shell before transfer.

Assisted reproductive technology (ART)
IVF & IUI

Treatments that handle eggs or embryos outside the body, such as IVF and ICSI.

Asthenozoospermia
Male fertility

Reduced sperm movement.

Azoospermia

No sperm found in the ejaculate.

B

C

Cervical mucus
Fertility basics

Fluid from the cervix that becomes clear and stretchy around ovulation.

Cervical stenosis
Clinics, laboratory & costs

A narrow or tight cervical canal that can make embryo transfer difficult.

Chromosome
Genetics

A packaged strand of DNA; humans normally have 46 in each cell.

Chronic endometritis
Female fertility

Persistent low-grade inflammation of the womb lining.

Chronic medicine benefit
South African healthcare & funding

Scheme cover for approved long-term medicines, subject to registration.

Cleavage-stage embryo
Eggs, sperm & embryos

An early embryo of about two to eight cells, on days 2 to 3.

Clinical pregnancy
Pregnancy after treatment

A pregnancy confirmed on ultrasound, not only by a blood test.

Co-payment
South African healthcare & funding

The portion of a bill you pay yourself.

Cold chain
Storage, power & practical realities

Keeping refrigerated medicines within their temperature range from pharmacy to injection.

Conception
Fertility basics

The start of pregnancy, when a fertilised egg implants in the womb lining.

Congenital uterine anomaly
Female fertility

A difference in the shape of the womb present from birth.

Consent form
Clinics, laboratory & costs

The signed document setting out what you agree to and for how long.

Controlled ovarian stimulation
Medicines & protocols

Using medicines to grow several follicles at once in a planned way.

Cryopreservation
Eggs, sperm & embryos

Storing eggs, sperm, embryos or tissue frozen in liquid nitrogen.

Cryostorage
Clinics, laboratory & costs

Long-term storage of frozen eggs, sperm or embryos in liquid nitrogen.

Culture medium
Clinics, laboratory & costs

The nutrient fluid embryos grow in inside the incubator.

Cycle cancellation
IVF & IUI

Stopping a treatment cycle before egg collection or transfer.

Cycle day
Fertility basics

The numbered day of your cycle, counting the first day of full bleeding as day 1.

Cycle fee
Clinics, laboratory & costs

The clinic's charge for the core IVF cycle, usually excluding medicines.

D

E

Ectopic pregnancy
Pregnancy after treatment

A pregnancy that implants outside the womb, usually in a fallopian tube.

Egg freezing
Donor treatment & family building

Collecting and vitrifying unfertilised eggs for use in the future.

Egg maturity
Eggs, sperm & embryos

Whether a collected egg is mature enough to be fertilised.

Egg retrieval
IVF & IUI

The procedure that collects eggs from the ovaries with a fine needle.

Elective single embryo transfer (eSET)
IVF & IUI

Choosing to transfer one embryo when more good embryos are available.

Embryo
Eggs, sperm & embryos

The developing group of cells formed after an egg is fertilised.

Embryo biopsy
Genetics

Removing a few cells from an embryo for genetic testing.

Embryo culture
Clinics, laboratory & costs

Growing embryos in the laboratory in a carefully controlled incubator.

Embryo freezing
Eggs, sperm & embryos

Vitrifying surplus or all embryos for transfer in a later cycle.

Embryo glue
IVF & IUI

A transfer medium containing hyaluronan, offered as an optional add-on.

Embryo grading
Eggs, sperm & embryos

The laboratory's scoring of how an embryo looks under the microscope.

Embryo transfer

Placing an embryo into the uterus through a fine catheter.

Embryo transfer catheter
Clinics, laboratory & costs

The fine soft tube used to place an embryo in the womb.

Embryologist
Clinics, laboratory & costs

The scientist who handles eggs, sperm and embryos in the laboratory.

Embryology report
Clinics, laboratory & costs

The laboratory's written summary of how your embryos developed.

Empty follicle syndrome
IVF & IUI

Follicles that yield no eggs at collection.

Endometrial biopsy
Tests & investigations

A small sample of womb lining taken for laboratory examination.

Endometrial receptivity
Pregnancy after treatment

How ready the womb lining is to accept an embryo.

Endometrial scratch
IVF & IUI

Deliberately grazing the womb lining before a cycle, an add-on with limited evidence.

Endometrial thickness
Tests & investigations

The measured depth of the womb lining on ultrasound.

Endometrioma
Female fertility

An ovarian cyst filled with old blood, caused by endometriosis.

Endometriosis
Female fertility

Tissue similar to the womb lining growing outside the womb, often causing pain.

ERA (endometrial receptivity analysis)
IVF & IUI

A biopsy-based test that claims to identify your personal transfer timing.

Erectile dysfunction
Male fertility

Difficulty getting or keeping an erection firm enough for sex.

Euploid
Genetics

An embryo with the expected number of chromosomes on testing.

Ex-gratia application
South African healthcare & funding

A request for a scheme to pay something it is not obliged to cover.

Expanded blastocyst
Eggs, sperm & embryos

A blastocyst whose cavity has grown and thinned the outer shell.

Expiry date
South African healthcare & funding

The date after which a medicine should not be used.

F

Falsified medicine
South African healthcare & funding

A fake or deliberately mislabelled product presented as a genuine medicine.

Fertile window
Fertility basics

The days in a cycle when sex is most likely to lead to pregnancy.

Fertilisation
Eggs, sperm & embryos

When a sperm enters an egg and the two sets of genetic material combine.

Fertilisation failure
Eggs, sperm & embryos

When few or no eggs fertilise after IVF or ICSI.

Fertilisation report
Eggs, sperm & embryos

The update the day after collection saying how many eggs fertilised.

Fertility
Fertility basics

The natural ability to conceive a pregnancy.

Fertility counsellor
Clinics, laboratory & costs

A registered counsellor or psychologist supporting people through treatment.

Fertility nurse
Clinics, laboratory & costs

The nurse coordinating your cycle, teaching injections and monitoring.

Fertility preservation
Donor treatment & family building

Storing eggs, sperm, embryos or tissue to protect future fertility.

Fetal heartbeat
Pregnancy after treatment

The heart activity seen on an early scan, usually from about six weeks.

Fetal pole
Pregnancy after treatment

The earliest visible form of the developing baby on a scan.

Folic acid

A B vitamin taken before conception to reduce the risk of neural tube defects.

Follicle tracking
Tests & investigations

A series of scans measuring follicles as they grow.

Follicular phase
Fertility basics

The first half of the cycle, when follicles grow and the womb lining thickens.

Formulary
South African healthcare & funding

The list of medicines a scheme will pay for.

Freeze-all cycle
IVF & IUI

An IVF cycle where every suitable embryo is frozen and transfer happens later.

Fresh embryo transfer
IVF & IUI

Transferring an embryo in the same cycle the eggs were collected.

Fridge thermometer
Storage, power & practical realities

A thermometer in the fridge that shows whether storage stayed in range.

Frozen embryo transfer (FET)
IVF & IUI

Thawing a previously frozen embryo and transferring it in a later cycle.

FSH (follicle-stimulating hormone)
Hormones

The pituitary hormone that stimulates follicles to grow.

FSH injection
Medicines & protocols

An injection containing follicle-stimulating hormone to grow follicles.

G

H

I

ICSI

A single sperm is injected directly into an egg during IVF.

Immature egg
Eggs, sperm & embryos

An egg collected before it is ready to be fertilised.

Implantation
Pregnancy after treatment

When an embryo attaches to and embeds in the lining of the womb.

Implantation window
Pregnancy after treatment

The short period when the womb lining is receptive to an embryo.

Incubator
Clinics, laboratory & costs

The controlled chamber where embryos are cultured.

Infertility
Fertility basics

Not conceiving after 12 months of regular unprotected sex (or 6 months from age 35).

Inherited condition
Genetics

A health condition passed down through genes in a family.

Injection technique
Medicines & protocols

How to prepare, give and dispose of fertility injections correctly.

Inner cell mass (ICM)
Eggs, sperm & embryos

The cluster of cells in a blastocyst that may develop into the fetus.

Intended parent
Donor treatment & family building

The person or couple who will be the child's legal parents.

Intramuscular injection
Medicines & protocols

An injection into a muscle, using a longer needle.

Intrauterine adhesions
Female fertility

Scar tissue inside the womb cavity that can stick the walls together.

Intrauterine insemination (IUI)
IVF & IUI

Placing prepared sperm directly into the womb around ovulation.

IVF (in vitro fertilisation)

Eggs are retrieved and fertilised in a laboratory, then an embryo is transferred.

IVF attrition
Eggs, sperm & embryos

The expected drop in numbers from follicles to eggs to embryos.

IVF laboratory
Clinics, laboratory & costs

The controlled laboratory where eggs, sperm and embryos are handled.

K

L

M

Male-factor infertility
Male fertility

Difficulty conceiving caused wholly or partly by sperm.

Mature egg (MII oocyte)
Eggs, sperm & embryos

An egg that has reached the stage where it can be fertilised.

Medical savings account
South African healthcare & funding

The scheme savings portion that can be used for day-to-day claims.

Medical scheme

A regulated health cover scheme that pays part of private healthcare costs.

Medicated FET
IVF & IUI

A frozen transfer where oestrogen and progesterone prepare the lining.

Medicine shortage
Storage, power & practical realities

A temporary unavailability of a particular product or presentation.

Menstrual cycle
Fertility basics

The monthly hormonal cycle from the first day of a period to the day before the next.

Micro-TESE
Male fertility

Microsurgical TESE, using an operating microscope to find the most promising tubules.

Mild IVF
IVF & IUI

IVF using lower doses of stimulation medicine, aiming for fewer eggs.

Miscarriage
Pregnancy after treatment

The loss of a pregnancy before 20 to 24 weeks.

Mock embryo transfer
Clinics, laboratory & costs

A practice run of the transfer, without an embryo.

Modified natural FET
IVF & IUI

A natural-cycle frozen transfer where a trigger injection fixes the timing.

Monitoring scan
IVF & IUI

A transvaginal scan during treatment to track follicles and the womb lining.

Morula
Eggs, sperm & embryos

A compact ball of cells, usually seen on day 4.

Mosaic embryo
Genetics

An embryo where the biopsy showed a mixture of normal and abnormal cells.

Mosaicism
Genetics

Different cells in the same embryo or person carrying different chromosomes.

Multiple pregnancy
Pregnancy after treatment

Carrying twins or more, which raises risks for mother and babies.

N

O

P

Pathology laboratory
Clinics, laboratory & costs

The laboratory that processes blood tests and tissue samples.

PCOS

Polycystic ovary syndrome, a common cause of irregular or absent ovulation.

Pelvic adhesions
Female fertility

Bands of scar tissue joining pelvic organs that should move freely.

Pelvic inflammatory disease (PID)
Female fertility

Infection of the upper reproductive tract that can scar the tubes.

Pelvic ultrasound
Tests & investigations

A scan of the womb, ovaries and pelvis, done through the abdomen or internally.

PESA
Male fertility

Percutaneous epididymal sperm aspiration — drawing sperm from the epididymis with a fine needle.

PGT (preimplantation genetic testing)
Genetics

Testing embryos for genetic or chromosomal conditions before transfer.

PGT-A
Genetics

Testing embryos for the correct number of chromosomes.

PGT-M
Genetics

Testing embryos for a specific inherited condition in the family.

PGT-SR
Genetics

Testing embryos when a parent carries a chromosome rearrangement.

Poor ovarian response
IVF & IUI

Fewer follicles and eggs developing than expected despite stimulation.

Pre-authorisation

Approval from your scheme before a procedure, needed for benefits to apply.

Pregnancy of unknown location (PUL)
Pregnancy after treatment

A positive pregnancy test with nothing yet visible on a scan.

Premature ovarian insufficiency (POI)
Female fertility

Ovaries stopping normal function before age 40.

Premature ovulation
IVF & IUI

Releasing eggs before they can be collected.

Prescribed Minimum Benefits (PMBs)

A defined set of conditions all medical schemes must cover.

Primary infertility
Fertility basics

Never having conceived a pregnancy.

Private fertility clinic
South African healthcare & funding

A privately funded clinic where most South African IVF is done.

Progesterone
Hormones

The hormone that prepares and maintains the womb lining after ovulation.

Progesterone injection
Medicines & protocols

Progesterone given by injection, usually into the muscle.

Progesterone pessary
Medicines & protocols

A progesterone capsule or tablet used vaginally for luteal support.

Progesterone support
Medicines & protocols

Progesterone medicine used after transfer to help maintain the lining.

Progesterone test
Tests & investigations

A blood test about a week before the expected period, to confirm ovulation.

Progressive motility
Male fertility

Sperm that swim purposefully forwards rather than in place.

Prolactin
Hormones

A pituitary hormone that, when raised, can stop ovulation.

Public sector fertility care
South African healthcare & funding

State-funded fertility services, available at a small number of academic hospitals.

R

S

SAHPRA
South African healthcare & funding

The regulator that authorises medicines and health products in South Africa.

Saline infusion sonography (SIS)
Tests & investigations

An ultrasound with sterile fluid in the womb to outline the cavity.

SASREG

The Southern African Society of Reproductive Medicine and Gynaecological Endoscopy.

Scheme appeal
South African healthcare & funding

Formally disputing a scheme's refusal to pay.

Scheme tariff
South African healthcare & funding

The rate a medical scheme pays for a service, often below what a provider charges.

Secondary infertility
Fertility basics

Difficulty conceiving after a previous pregnancy.

Section 21 authorisation
South African healthcare & funding

SAHPRA permission to use an unregistered medicine for a named patient.

Self-payment gap
South African healthcare & funding

The period after savings run out but before above-threshold benefits start.

Semen analysis

A laboratory test of sperm number, movement and shape.

Semen volume
Male fertility

How much fluid is produced in one ejaculate.

Sharps container
Storage, power & practical realities

A puncture-proof container for used needles and pens.

Sharps disposal
Medicines & protocols

Safe disposal of used needles in a puncture-proof container.

Single embryo transfer (SET)
IVF & IUI

Transferring one embryo to avoid the risks of twins.

Singleton pregnancy
Pregnancy after treatment

A pregnancy with one baby.

Solo parent
Donor treatment & family building

Someone choosing to have a child on their own, usually with donor gametes.

Sperm concentration
Male fertility

How many sperm there are in each millilitre of semen.

Sperm count
Male fertility

The total number of sperm in the whole ejaculate.

Sperm DNA fragmentation
Male fertility

Breaks in the genetic material carried inside sperm.

Sperm DNA fragmentation test
Tests & investigations

A specialised semen test measuring DNA damage inside sperm.

Sperm freezing
Donor treatment & family building

Storing a semen or surgically retrieved sample frozen for later use.

Sperm morphology
Male fertility

The percentage of sperm with a normal shape.

Sperm motility
Male fertility

The proportion of sperm that are moving.

Stimulation cycle
Medicines & protocols

The phase of IVF where injections encourage several follicles to grow.

Stimulation protocol
Medicines & protocols

The individual plan of which medicines you take, in what order.

Storage consent
Clinics, laboratory & costs

Your written agreement about keeping frozen eggs, sperm or embryos.

Storage fee
Clinics, laboratory & costs

An ongoing charge for keeping frozen eggs, sperm or embryos.

Subcutaneous injection
Medicines & protocols

An injection into the fatty layer just under the skin.

Subfertility
Fertility basics

Reduced fertility — conception is slower than average but still possible.

Surgical sperm retrieval
Male fertility

Collecting sperm directly from the testis or epididymis with a procedure.

Surrogacy
Donor treatment & family building

Another woman carrying a pregnancy for the intended parents.

Surrogate
Donor treatment & family building

The woman who carries the pregnancy for the intended parents.

T

Temperature excursion
Storage, power & practical realities

When a refrigerated medicine goes outside its safe temperature range.

Teratozoospermia
Male fertility

A high proportion of abnormally shaped sperm.

TESA
Male fertility

Testicular sperm aspiration — drawing sperm directly from the testis with a needle.

TESE
Male fertility

Testicular sperm extraction — taking small pieces of testicular tissue to find sperm.

Testosterone
Hormones

The main male sex hormone; also present in smaller amounts in women.

Thaw
Eggs, sperm & embryos

Bringing frozen material back to working temperature for use.

Theatre fee
Clinics, laboratory & costs

The separate charge for use of the operating theatre and its staff.

Thin endometrium
Female fertility

A womb lining that stays thinner than clinics usually want before transfer.

Thrombophilia testing
Tests & investigations

Blood tests for clotting tendencies, used selectively after pregnancy loss.

Time-lapse embryo imaging
Clinics, laboratory & costs

Incubators that photograph embryos continuously without disturbing them.

Timed intercourse
IVF & IUI

Planning sex around the fertile window, sometimes with scans or medicines.

Transvaginal ultrasound
Tests & investigations

An internal scan giving a clear view of the ovaries and womb.

Travelling with fertility medicines
Storage, power & practical realities

Carrying medicines and needles safely on journeys within or outside South Africa.

Treatment add-on
IVF & IUI

An optional extra offered alongside standard treatment, often at extra cost.

Trigger injection
Medicines & protocols

The final injection that matures the eggs before collection.

Trophectoderm (TE)
Eggs, sperm & embryos

The outer cell layer of a blastocyst that may form the placenta.

TSH (thyroid-stimulating hormone)
Hormones

A blood test of thyroid function, checked because thyroid problems affect fertility.

Tubal factor infertility

Infertility caused by blocked or damaged fallopian tubes.

Two-week wait

The period between transfer or ovulation and a reliable pregnancy test.

U

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W

Y