Medicines & protocols
Down-regulation uses a GnRH agonist over one to three weeks to quieten the pituitary so that follicle growth can be started from a controlled baseline and an early LH surge is prevented. A scan and sometimes a blood test confirm suppression before stimulation begins. Hot flushes, headaches and mood changes are common while down-regulated.
Also known as: downreg, DR, suppression
Related South Africa guides
Sources
- ESHRE guidelines and patient information
Last reviewed: 8 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.