Medicines & protocols
In a long protocol, a GnRH agonist is started in the cycle before stimulation, often around day 21, and continues until the trigger. It gives a high degree of cycle control and is still used in endometriosis and some other situations, but it involves more days of injections than the antagonist approach.
Also known as: long down-regulation protocol, agonist protocol
Related South Africa guides
Sources
- ESHRE guidelines and patient information
Last reviewed: 8 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.