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Fertility Glossary

Y chromosome microdeletion

Missing segments of the Y chromosome affecting sperm production.

Genetics

Deletions in the AZFa, AZFb and AZFc regions are tested in severe oligospermia or azoospermia. AZFc deletions often still allow sperm retrieval, while complete AZFa or AZFb deletions usually do not — which is exactly why the test is done before surgery. Any son conceived will inherit the deletion, so genetic counselling is offered.

Also known as: AZF deletion, Y microdeletion

Sources

  • Canadian Urological Association

Last reviewed: September 9, 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.

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