Lynch syndrome

Lynch syndrome is an inherited condition, caused by a pathogenic variant in one of several DNA mismatch repair genes, that substantially raises the lifetime chance of certain cancers, notably colorectal and endometrial cancer, and is inherited in an autosomal dominant pattern. It is usually identified through genetic testing prompted by a personal or family history of these cancers at a young age, or by tumour testing. For reproductive planning, Lynch syndrome can be relevant where a diagnosis of endometrial cancer at a young age raises questions about fertility-sparing treatment, and where carriers consider whether to test embryos for the familial variant using PGT-M. As with other inherited cancer syndromes, decisions are highly individual and are best supported by genetic counselling alongside oncology and fertility specialists.

Also known as: Lynch syndrome cancer risk, hereditary colorectal cancer syndrome

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.