PGT-SR (preimplantation genetic testing for structural rearrangements)

PGT-SR (preimplantation genetic testing for structural rearrangements) is used when one partner carries a balanced chromosomal rearrangement, such as a translocation or inversion, identified on a karyotype. Carriers of balanced rearrangements are usually healthy themselves but can produce a higher proportion of eggs or sperm with unbalanced chromosome material, which is linked to a higher chance of miscarriage or, rarely, a child with a chromosomal condition. PGT-SR analyses embryo biopsy samples to identify embryos with a balanced or normal chromosome set for that rearrangement, aiming to lower the chance of miscarriage from this specific cause. It does not remove all chance of miscarriage or guarantee a healthy child, and it is usually recommended after genetic counselling has confirmed the parental karyotype finding and its relevance.

Also known as: PGT-SR, preimplantation genetic testing for structural rearrangements

Last reviewed: 9 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.