Genetics
Microdeletions in the AZF regions of the Y chromosome cause severely reduced or absent sperm production. Testing is recommended before ICSI in severe male factor, because the result predicts the chance of successful surgical retrieval and because any son conceived will inherit the same deletion.
Also known as: AZF deletion, Y microdeletion
Sources
- Royal Australian and New Zealand College of Obstetricians and Gynaecologists (ranzcog.edu.au)
- Royal College of Pathologists of Australasia (rcpa.edu.au)
Last reviewed: 10 September 2026. Written by the Antega Editorial Team. General information only — always follow the advice of your own clinic, doctor or pharmacist.