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Fertility Glossary

Klinefelter syndrome

An extra X chromosome in males (47,XXY), often causing very low or absent sperm.

Genetics

Klinefelter syndrome is a common genetic cause of azoospermia. Sperm can sometimes still be found in the testis by microTESE, particularly when retrieval happens earlier in adult life, so referral to a reproductive urologist matters. Hormone and bone health follow-up is part of long-term care.

Also known as: 47 XXY, XXY

Sources

  • Canadian Urological Association

Last reviewed: September 9, 2026. Written by the Antega Editorial Team. General information only โ€” always follow the advice of your own clinic, doctor or pharmacist.

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